ANALYSIS OF CARDIOVASCULAR RISK FACTORS AND SPECKLE-TRACKING PARAMETERS IN PATIENTS WITH MALIGNANT HEMATOLOGICAL DISEASES

The study aimed to identify the post-chemotherapy variation of myocardial deformation parameters evaluated by speckle-tracking echocardiography and their evolution in the cardiovascular evaluation of patients with hematological malignancies. Furthermore, the study of the post-chemotherapy variation of these parameters, according to classic cardiovascular risk factors, contributes to better risk stratification of the myocardial dys-function associated with cancer therapy. We describe the changes over 12 months of myocardial de formation study, evaluated by speckle-tracking echocardiography, and the relationship between changes in echo cardio-graphic parameters and cardiovascular risk factors. We report that 13.46% of patients in the study had positive cardiovascular here docolateral antecedents, 32.69% were diagnosed with HTA (17 patients), 17.31% with di-abetes (9 patients), 55.77% with dyslipidemia (29 patients), and 5.77% were active smokers (3 patients). The decreased GLS between the two moments, pre-chemotherapy and at 12 months was statistically significant, influenced by hypertension and dyslipidemia. Early myocardial dysfunction associated with cancer therapy in hypertensive patients and those with dyslipidemia, diagnosed by decreased GCS by more than 15% of the pre-chemotherapy value, was reported in 50–75% of cases after the sixth course of therapy. The global radial systolic strain GRS showed changes between the two moments evaluated in our study, but these were not constant, they did not have a significant magnitude, and they only appeared in a small number—under 10% of the studied patients.