DR JOHN HOLT'S UHF RESONANCE – SENSITIVITY FOR CANCER RADIOTHERAPY AN HYPOTHESIS (Number 3)

Dr John Holt (Radiotherapist, Western Australia) trialed radiowave UHF 434 MHz to treat cancer, claiming that, if it were administered in the 30 minutes prior to radiotherapy (RT), that it increased the cancers' sensitivities to RT greatly. With no satisfactory explanation for this and with the retirement of Dr Holt, it has been neglected. A recent hypothesis suggested that the UHF generated NAD+ and this fueled the deacetylase SIRTUIN2 (SIRT2) which moved into the cell nuclei and perturbed a number of potential steps involving acetylase reactions. The hypothesis suggests that the activated SIRT2 disturbed the cells' DNA damage checkpoint mechanisms, increasing the sensitivity to RT. Conclusion: Recent advances may support Dr John Holt's claims that UHF can sensitize cancers to radiotherapy.