DR JOHN HOLT'S UHF RESONANCE – SIRT2, PHENOTYPES, ACTIN & NUCLEI: AN HYPOTHESIS (NUMBER 2)

The proposal here is that the radiowave energy used by Dr John Holt (Radiotherapist, Western Australia) to treat cancer, caused NAD+ to be generated. This fuelled the deacetylase SIRT2, which degraded cortical actin, depriving the plasma membrane of its support base needed by E-cadherin for cell-to-cell adhesion and the maintenance of cell morphology: the post-treated appearance then resembling an epithelial-like cell phenotype, yet with gaps between the cells and poor epithelial-like cell-to-cell relationships. This hypothesis suggests that the cell changes follow the action of SIRTUIN2 activity stimulated by the NAD+ and not the factors typically involved with EMT/MET. Conclusion: Holt's UHF treatments had effects on cancer cytology not well appreciated previously.