DIAGNOSTIC, CLASSIFICATION AND MANAGEMENT OF ENDOMETRIAL PRECANCEROUS LESION

Endometrial hyperplasia (EH) is a pathological condition characterised by hyperplastic changes in endometrial glandular and stromal structures lining the uterine cavity. Endometrial hyperplasia known as a precursor lesion to adenocarcinoma of the endometrium. Most of these risk factors involve exposure of the endometrium to continuous estrogen unopposed by progestin. Unopposed estrogenic stimulation of the endometrium causes proliferative glandular epithelial changes, including glandular remodelling relative to the stroma, resulting in variably shaped, irregularly distributed glands. The classification system currently most widely used is, which uses architectural features and cytological atypia (glandular complexity and nuclear atypia) to identify precursor lesions, termed atypical endometrial hyperplasia (AEH).For New WHO 2014 classification of endometrial hyperplasia consist of Non-atypical endometrial hyperplasia (benign hyperplasia) and Atypical endometrial hyperplasia or Endometrial Intraepithelial Neoplasia (EIN)/well differentiated carcinoma. Management is guided by the following clinical factors, such as type of EH (i.e., with or without atypia), menopausal status, desire for fertility in premenopausal patients, contraceptive needs in premenopausal patients.